{"id":2163,"date":"2022-02-22T12:09:17","date_gmt":"2022-02-22T12:09:17","guid":{"rendered":"https:\/\/gocchi.org\/cancer-gastrico\/"},"modified":"2022-08-28T16:06:45","modified_gmt":"2022-08-28T16:06:45","slug":"cancer-gastrico","status":"publish","type":"page","link":"https:\/\/gocchi.org\/?page_id=2163","title":{"rendered":"C\u00e1ncer G\u00e1strico"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2163\" class=\"elementor elementor-2163\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af911c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af911c0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f087906\" data-id=\"f087906\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6fafc46 elementor-widget elementor-widget-spacer\" data-id=\"6fafc46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a096a07 elementor-widget elementor-widget-heading\" data-id=\"a096a07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">C\u00e1ncer G\u00e1strico<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b7bed0f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b7bed0f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5b4a8ad\" data-id=\"5b4a8ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92934bc elementor-widget elementor-widget-toggle\" data-id=\"92934bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1531\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1531\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Gocchi 2009-01 \"PRECISO\"<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1531\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1531\"><p>Estudio descriptivo de una serie cl\u00ednica prospectiva de pacientes con c\u00e1ncer g\u00e1strico localmente avanzado tratados con Quimioterapia perioperatoria y<br \/>cirug\u00eda. Se busca establecer el porcentaje de cirug\u00edas R0 con Quimioterapia preoperatoria.<\/p><ul><li>Investigador Principal Nacional: Dra. Bettina M\u00fcller<\/li><li>Status del protocolo en Chile: abierto,<br \/>en proceso de enrolamiento. Se incluir\u00e1n 75 pacientes consecutivos en un<br \/>per\u00edodo de 12 meses.<\/li><li>Resultados:\u00a0Resultados<br \/>preliminares presentados en el Simposio Latinoamericano de<br \/>Gastroenterolog\u00eda Oncol\u00f3gica SLAGO, 2013 por Dra. Bettina M\u00fcller,<br \/>investigadora principal del estudio GOCCHI 2009-01.<\/li><li>Centros participantes: Instituto Nacional del C\u00e1ncer y Hospital San Borja Arriar\u00e1n.<\/li><\/ul><div>Para ver m\u00e1s informaci\u00f3n haga\u00a0<a href=\"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01633203?term=GOCCHI&amp;rank=1\" target=\"_blank\" rel=\"noopener\">Click Aqui<\/a><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1532\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1532\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Gocchi 2000-01 RATONES<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1532\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1532\"><p>Los resultados de este estudio fueron presentados recientemente en el Congreso de la Sociedad Europeo de Radioterapia y Oncolog\u00eda (European Society for Therapeutic Radiology and Oncology) ESTRO 29<\/p><p>RAToNES es un estudio multic\u00e9ntrico nacional, fase III randomizado, en que su Investigador Principal es el Dr. Ram\u00f3n Baeza.<\/p><p>Este estudio compara el esquema INT 0116 en pacientes con c\u00e1ncer g\u00e1strico (radioterapia localizada y quimioterapia con 5FU) con el esquema de irradiaci\u00f3n abdominal total y 5FU con el que varios grupos chilenos han desarrollado una razonable experiencia.<\/p><p><strong>Abstract<\/strong><\/p><p><strong>ADJUVANT TREATMENT OF LOCALLY ADVANCED GASTRIC CANCER COMPLETELY RESECTED. A PHASE III STUDY: TOTAL ABDOMINAL IRRADIATION WITH CONCOMITANT CHEMOTHERAPY OR EXTENDED NODAL (RATONES) WITH CONCOMITANT CHEMOTHERAPY.<\/strong><\/p><p>M. Gonz\u00e1lez-Domingo<sup>1<\/sup>, M. R. Baeza B.2, O. Giannini T.1, C. del Castillo<sup>2<\/sup><br \/>1 INSTITUTO ONCOL\u00d3GICO, Vi\u00f1a del Mar, Chile.<br \/>2 INSTITUTO DE RADIOMEDICINA (IRAM), Santiago, Chile<\/p><p><strong>Purpose<\/strong>: Adjuvant radio-chemotherapy after resection is routinely administered in locally advanced gastric cancer. The recurrence post-treatment are fundamentally intra-abdominal. We investigated the effect of abdominal irradiation with concomitant chemotherapy in patients with resectable adenocarcinoma of the stomach.<\/p><p><strong>Materials<\/strong>: From 2000 to 2006, 108 patients with completely resected locally advanced gastric adenocarcinoma were randomly assigned in a 1:1 ratio to receive total abdominal irradiation (RAT) or extended nodal irradiation (NES) both with concomitant chemotherapy. Treatment was either total-or sub-total gastrectomy, followed by RAT, 2100 cGy\/21 fractions plus a 2400 cGy\/16 fractions boost to the tumor bed or tumor bed plus nodal irradiation, 4500 cGy\/25 fractions. Concomitant chemotherapy consisted of either 5-uorouracil (5-FU) 300 mg\/m2 i.v. for 5 days rst and 5th week or 225 mg\/m2 continuous infusion during irradiation in RAT group. NES received similar chemotherapy followed by two additional cycles. The primary endpoint was overall survival (OS). Analysis was by intention to treat.<\/p><p>\u00a0<\/p><p><strong>Results<\/strong>: 53 patients (median age 58 years, range 35-74) were randomized to NES and 55 patients (57 years, range 26-78) to RAT. 46\/55 (84%) of patients in RAT group completed treatment and 49\/53 (92%) in NES group did so. There were none treatment related deaths. With a median follow-up of 38 months, 5 years overall survival was 47.3% in RAT group and 37.7% in NES (hazard ratio for death (HR) 0.88; 95 percent confidence interval, 0.54 to 1.42; P = 0.624). The median overall survival in RAT group was 46 months, as compared with 37 months in NES group. In a exploratory analysis, the 5- years overall survival in patients with involvement less than six lymph node and serosa (T3N_5) was 76.5% for those who received RAT, which was signicantly better than the 44.4% 5-year survival observed in NES group (p=0.04) Conclusions: Adjuvant radiotherapy with concomitant chemotherapy either total abdominal irradiation or tumor bed plus nodal irradiation are effective and safe treatment options for patients with locally advanced gastric cancer completely resected.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-762c0b7 elementor-widget elementor-widget-spacer\" data-id=\"762c0b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d6c1fd elementor-widget elementor-widget-button\" data-id=\"0d6c1fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/gocchi.org\/estudios\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-arrow-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Volver<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6274efa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6274efa\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b0ea29f\" data-id=\"b0ea29f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-02ddcba elementor-widget elementor-widget-spacer\" data-id=\"02ddcba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>C\u00e1ncer G\u00e1strico Gocchi 2009-01 \u00abPRECISO\u00bb Estudio descriptivo de una serie cl\u00ednica prospectiva de pacientes con c\u00e1ncer g\u00e1strico localmente avanzado tratados con Quimioterapia perioperatoria ycirug\u00eda. Se busca establecer el porcentaje de cirug\u00edas R0 con Quimioterapia preoperatoria. Investigador Principal Nacional: Dra. Bettina M\u00fcller Status del protocolo en Chile: abierto,en proceso de enrolamiento. Se incluir\u00e1n 75 pacientes consecutivos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2163","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/pages\/2163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gocchi.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2163"}],"version-history":[{"count":6,"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/pages\/2163\/revisions"}],"predecessor-version":[{"id":2608,"href":"https:\/\/gocchi.org\/index.php?rest_route=\/wp\/v2\/pages\/2163\/revisions\/2608"}],"wp:attachment":[{"href":"https:\/\/gocchi.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}